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Seminar on Tuesday, May 24, 2016

May 24, 2016 @ 3:30 pm - 5:00 pm

Comparison of adaptive designs for dose finding in phase I clinical trials

Full Title: Comparison of adaptive designs for dose finding in phase I clinical trials
Speaker: Dr. M. Iftakhar Alam
Institute of Statistical Research and Training, University of Dhaka, Dhaka-1000, Bangladesh
Date/Time: Tuesday, May 24, 2016, 3:30 p.m.
Venue: ISRT Seminar Room

 

ABSTRACT

The Continual reassessment method is a model based procedure that has been in the literature to determine the maximum tolerated dose in phase I clinical trials. The maximum tolerated dose can also be found under the framework of D-optimum design. This paper investigates the two methods to explore any potential differences between them. Simulation studies for six plausible dose-response scenarios show that the D-optimum design can work well over the continual reassessment method in many cases. The D-optimum design has also been found to allocate doses from the extremes of design region to the patients in a trial.

Keywords: Dose finding studies; Phase I trial; Maximum tolerated dose; Continual re-assessment method; D-optimum design.

Details

Date:
May 24, 2016
Time:
3:30 pm - 5:00 pm
Event Category:

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